Characterizing the heterogeneity in 5-aminolevulinic acid–induced fluorescence in glioblastoma
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چکیده
منابع مشابه
heterogeneity within the orientalist discourse: representation of the orient in womens travelogues and mens paintings
from 1950s onward, new theories and critical approaches burgeoned across humanities. these theories were context-oriented; as a result, the analysis of discursive practices gained significance. thus, social, political, historical and cultural discourses that have been hitherto marginalized and considered inferior to literary texts, were introduced as important texts to be analyzed by critics. o...
Optical touch pointer for fluorescence guided glioblastoma resection using 5-aminolevulinic acid.
BACKGROUND AND OBJECTIVE Total tumor resection in patients with glioblastoma multiforme (GBM) is difficult to achieve due to the tumor's infiltrative way of growing and morphological similarity to the surrounding functioning brain tissue. The diagnosis is usually subjectively performed using a surgical microscope. The objective of this study was to develop and evaluate a hand-held optical touch...
متن کاملFluorescence Spectroscopy for Quantitative Demarcation of Glioblastoma Using 5-Aminolevulinic Acid
Total resection of glioblastoma, the highly malignant brain tumor, is difficult to accomplish due to its diffuse growth and similarity to the surrounding brain tissue. A total resection is proven to increase patient survival. The aim of this thesis was to evaluate fiber-optical based fluorescence spectroscopy for quantitative demarcation of malignant brain tumors during the surgery. Five-aminol...
متن کاملCharacterizing Mutational Heterogeneity in a Glioblastoma Patient with Double Recurrence
Human cancers are driven by the acquisition of somatic mutations. Separating the driving mutations from those that are random consequences of general genomic instability remains a challenge. New sequencing technology makes it possible to detect mutations that are present in only a minority of cells in a heterogeneous tumor population. We sought to leverage the power of ultra-deep sequencing to ...
متن کامل5-Aminolevulinic Acid Fluorescence in High Grade Glioma Surgery: Surgical Outcome, Intraoperative Findings, and Fluorescence Patterns
BACKGROUND 5-Aminolevulinic acid (5-ALA) fluorescence is a validated technique for resection of high grade gliomas (HGG); the aim of this study was to evaluate the surgical outcome and the intraoperative findings in a consecutive series of patients. METHODS Clinical and surgical data from patients affected by HGG who underwent surgery guided by 5-ALA fluorescence at our Department between Jun...
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ژورنال
عنوان ژورنال: Journal of Neurosurgery
سال: 2020
ISSN: 0022-3085,1933-0693
DOI: 10.3171/2019.2.jns183128